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Prof. Ole G. Mouritsen
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Conference abstract - invited talk:
- O. G. Mouritsen and O. S. Andersen (eds.) In Search of a New Biomembrane Model, Biol. Skr. Dan. Vid. Selsk. 49, 75-82 (1998).
- O. G. Mouritsen and K. Jorgensen, Small scale lipid membrane structure, Curr. Opin. Struct. Biol. 7, 518-527 (1997).
- O. G. Mouritsen, Self-assembly and organization of lipid- protein membranes, Curr. Opin. Coll. Interface Sci. 3, 78-87 (1998).
- L. K. Nielsen, T. Bjornholm, and O. G. Mouritsen, Fluctuations caught in the act, Nature 404, 352 (2000).
- L. K. Nielsen, A. Vishnyakov, K. Jorgensen, T. Bjornholm, and O. G. Mouritsen, J. Phys.: Condens. Matt. Phys. 12, A309-A314 (2000).
- O. G. Mouritsen and K. Jorgensen, A new look at lipid-membrane structure in relation to drug research, Pharm. Res. 15, 1507-1519 (1998).
Membranes and magic bullets
There is increasing theoretical and experimental evidence indicating that small- scale domain structure and dynamical heterogeneity develop in lipid membranes as a consequence of the many-particle character of the system. This small-scale structure occurs in the nano-meter range and can be perceived as either density fluctuations, compositional fluctuations, or bilayer thickness fluctuations. Theoretical predictions are confronted with recent experimental data obtained from e.g. fluorescence spectroscopy and atomic-force microscopy. The nano-scale structure is shown to be important for controlling phospholipase activity at membranes. The insights into the physics of lipid membranes and their nano-scale structure can be used as lessons for rational design of liposome-based drug-delivery systems.References: